Exciting opportunity within Targeted Protein Degradation in Europe
Are you ready to lead the charge in redefining the boundaries of drug discovery? Join a pioneering biotech as Head of Chemistry and shape the future of targeted protein degradation. This is a rare opportunity to build and lead a world-class chemistry team working at the forefront of a modality reshaping the way diseases are treated.
About the Company
This early-stage biotech is focused on leveraging targeted protein degradation and chemoproteomics to unlock previously undruggable targets. With cutting-edge technologies including DEL and D2B approaches, they are rapidly advancing a platform with significant therapeutic potential. The company brings together experienced leaders in chemistry, biology, and computation, with a shared passion for innovation and impact.
What you’ll be doing
As Head of Chemistry, you will:
- Lead and grow a high-performing team in medicinal and synthetic chemistry
- Define the strategic direction of chemistry across discovery programmes
- Drive design, synthesis, and optimisation of small molecules to support TPD programmes
- Apply SAR, ADME, and drug-likeness principles to guide decision-making
- Integrate DEL and D2B screening to identify novel scaffolds
- Collaborate with cross-functional teams including biology, pharmacology, and computation
- Represent the company externally with partners, CROs, and collaborators
- Contribute to IP strategy and ensure scientific excellence across projects
Experience you’ll need
- PhD in organic or medicinal chemistry (or related field) with 10+ years in drug discovery
- Proven track record of advancing small molecules into development
- Deep understanding of SAR, drug-likeness, ADME, and degradation principles
- Strong leadership and team-building skills, with experience mentoring scientists
- Excellent communication and collaboration in cross-functional and external environments
- Experience with early to mid-stage biotech or pharma organisations
- Exposure to targeted protein degradation is strongly preferred
What’s on offer
- Competitive compensation with long-term incentives
- Direct influence on scientific direction and team growth
- Opportunity to work with a passionate and ambitious leadership team
- Access to world-class resources in a fast-paced, collaborative environment
- Flexibility for international candidates
The process
We are actively interviewing and looking to appoint as soon as the right person is identified. Early conversations will be exploratory and confidential. If you’re interested in finding out more, reach out directly to schedule an initial conversation.
About us
We specialise in supporting innovative life sciences companies across Europe and the US, particularly those working at the intersection of technology and biology. We partner closely with emerging biotechs to help them grow exceptional teams and make meaningful scientific progress.