The Drug Discovery Division of our partner is currently looking for an Experienced Computational Chemist to join their team and support their development program. This position offers an opportunity to work for a company that is operating in a critical sector of the economy and has a strong and exciting future.
The successful candidate will have a PhD in a field related to Computational Chemistry combined with significant experience in a world-class small molecule drug discovery organisation. Experience in structure and ligand-based drug discovery in addition to scripting and/or pipelining tools is also required. The role is to support and drive small molecule drug discovery projects from hit-finding, through lead generation and lead optimisation to candidate selection, utilising in-house resources and jointly with partner organisations.
Our partner is a dynamic, fast-growing organisation, with an enviable reputation for leading-edge science, offering contract research services to some of the world’s leading pharmaceutical companies, solving what were believed to be unsolvable scientific challenges. Their team of experts believes in their ability to relentlessly push forward the boundaries of scientific excellence, delivering solutions for their clients, and always operating ethically and with integrity. They take pride in their professionalism and commitment to always deliver their very best work.
Responsibilities:
- Support and drive small molecule drug discovery projects from hit-finding, through lead generation and lead optimization to candidate selection, utilising in-house resources and jointly with partner organisations.
- Through scientific leadership and collaboration with colleagues, provide clear data analyses, actionable hypotheses and ideas to steer the overall project and, in particular, medicinal and synthetic chemistry project contributions.
- Present plans, tactics and achievements to external partners and to internal stakeholders including project and Senior Management.
- Provide flexible support to the scientific and operational needs of the department.
- Be willing to develop new skills and assume responsibility for new capabilities.
Ensure:
- Timely application of computational approaches.
- Data and hypotheses communicated effectively.
- Active engagement in decision-making.
As the computational chemist on client project teams:
- the candidate will creatively and proactively apply computational methods, including structure-based drug design, homology modelling, conformational analysis, docking, virtual screening, molecular dynamics, quantum methods, cheminformatics, diversity/similarity analysis
- QSAR/machine learning/artificial intelligence to the analysis of project data and design of project compounds to advance multiple drug discovery projects.
Requirements:
- PhD in chemistry or closely related discipline e.g... Computational physical or theoretical chemistry or structural biology
- Multi-year experience in world-class small molecule drug discovery organization(s)
- Structure and ligand-based drug discovery
- Scripting and/or pipelining tools
- Combine the above to contribute to drug discovery
- Strong familiarity with a wide range of current computational chemistry software
- Decide and communicate scientific/tactical choices
- Decide and communicate scientific/tactical choices
- Excellent motivation and team-building skills
- Analytical and Problem-solving skills
- Excellent interpersonal skills
- Excellent organization skills, focused on execution, with strong attention to detail
- IT skills with a good working knowledge of MS Office
- Able to work across geographies and cultures
What will you get:
- A competitive salary and a progressive and comprehensive suite of employee benefits.
- A state-of-the-art working environment on site.
- An exciting opportunity for growth and development.
- Support for funding for relevant training and development programmes.